Cell Separation Reagents

MACS® Cell Separation
Select the best technology for your cell isolation

MACS Technology enables the magnetic separation of cell populations based on surface antigens. It is a fast and gentle method for the isolation of viable and functional cells by labeling epitopes with specific antibodies conjugated to superparamagnetic beads.

The MACS Technology portfolio provides a broad range of options for the isolation of virtually any cell type. Thereby, you enjoy the freedom to choose the cell isolation method that is best for your cells and your specific requirements. Our portfolio offers consistent, reliable cell separation solutions across basic and clinical research.

With MACS Technology, you are sure to select the best.

Which cell separation technology fits your needs?
Starting from single-cell suspensions or blood products?

Need your cells untouched or from positive selection?

Explore your options below and find more information on the technique

that best fits your isolation demands.

Positive selection

Untouched isolation

Single-cell suspensions
e.g. PBMCs, dissociated tissues (incl. tumors)

MACS® MicroBeads

Columns
Nano-sized MicroBeads
REAlease® MicroBeads

MACS® Cell Isolation Kits

Columns
Nano-sized MicroBeads

Blood products
e.g. whole blood, buffy coat, apheresis products

StraightFrom® MicroBeads

Columns
Nano-sized MicroBeads

MACSxpress® Cell Isolation Kits

Column-free
Micro-sized MACSxpress Beads

MACS® MicroBeads - magnetic beads for gentle cell isolation

Outstanding cell separation techniques with kits that feature MACS® MicroBead Technology, tailored to fit your target cell separation needs. Our kits have a unique combination of nano-sized MACS MicroBeads with a high magnetic gradient in our MACS Columns enables gentle cell isolation techniques with minimal labeling.

MACS MicroBeads are the smallest beads available on the market. They are non-toxic, biodegradable, and compatible with all downstream applications from basic research to clinical.

MACS® MicroBeads are 50-nm superparamagnetic particles that are conjugated to highly specific antibodies against a particular cell surface antigen. Due to their small size, the beads do not activate cells. Furthermore, MACS MicroBeads do not have to be removed for any downstream application.

• MACS MicroBead Technology gives you the most flexible, most proven method for cell separation

• Minimal cell labeling with nano-sized MicroBeads ensures preservation of cellular integrity and characteristics

• Used in over 55,000 clinical cellular treatments to date

MACS MicroBead Technology owes its longstanding success to the ingenious combination of nano-sized superparamagnetic beads and a strong magnetic field in our MACS Columns.

Only this technology ensures minimal labeling of target cells and the preservation of cellular properties.

Cell separation with MACS MicroBeads is based on three easy steps: magnetic labeling, magnetic separation, and elution of labeled cells.

Magnetic beads for cell separation from blood products - StraightFrom® Technology

Magnetic cell separation with StraightFrom® Technology delivers highly pure cells directly from whole blood, buffy coat, LRSC, and Leukopak® (Leukopak is a trademark of StemExpress) with all the benefits of MACS® MicroBeads, as well as easy and fast enrichment of leukocytes without density gradient centrifugation and erythrocyte lysis.

StraightFrom REAlease® Technology is the newest branch of the StraightFrom Technology family. It enables full flexibility with bead-free and label-free target cells.

StraightFrom Technology can be used with the autoMACS® Pro Separator, the MultiMACS™ Cell24 Separator Plus, or manual separators to purify leukocyte subsets. The purified cells are well-suited for further flow cytometric analyses, molecular biology applications, and functional studies.

Cell isolation directly from blood products without density gradient centrifugation StraightFrom® MicroBeads allow magnetic isolation of various leukocyte subsets from different starting materials by positive selection. With these kits, isolation of leukocyte subsets has never been easier and quicker. In contrast to conventional methods, StraightFrom Technology does not require density gradient centrifugation.

• Start directly with whole blood, buffy coat, and leukocyte reduction system chamber (LRSC)

• The isolated target cells are immediately ready for any downstream application

• Simple protocol with only a few handling steps

MACSxpress® Technology

With high speed to untouched target cells MACSxpress® Technology enables the fastest large-scale isolation of untouched cells directly from whole blood – without the need for any centrifugation.

Micro-sized MACSxpress Beads allow for minimal labeling to prevent non-specific labeling and activation of target cells. Nontarget cells are removed by immunomagnetic depletion.

Simultaneously, erythrocytes are sedimented to yield target cells of exceptional purity.

• Go from whole blood to pure cells within 20 minutes

• Obtain untouched target cells directly from whole blood

• No density gradient centrifugation, erythrocyte lysis or cell counting required

Direct cell isolation for diagnostic research with MACSPrep™ Kits*

Cell preparation with the MACSprep™ Portfolio allows for cell isolation directly from routine diagnostic samples without time-consuming density gradient centrifugation.

The enriched cells are suitable for various diagnostic analyses, such as flow cytometry, sequencing, or cytogenetic studies.

With the minimal hands-on cell preparation procedure, user safety when handling samples of unknown origin is increased.

The streamlined automated cell isolation solution is also compatible with MACSprep Products.

* For research use only.

MACS® Cell Separation Select the best technology for your cell isolation

MACS® MicroBeads - magnetic beads for gentle cell isolation

MACS® Cell Separation
Select the best technology for your cell isolation